Journal: medRxiv
Article Title: Effects of Isocaloric Early vs. Late Time-Restricted Eating on Insulin Sensitivity, Cardiometabolic Health, and Internal Circadian Time in Women with Overweight or Obesity
doi: 10.1101/2024.10.05.24314120
Figure Lengend Snippet: Adipokine and Cytokine Levels. Adipokine leptin (A) was decreased after both eTRE (-8080 pg/mL; 95% CI -15995 to -166 pg/mL, P = .02) and lTRE (-10763 pg/mL; 95% CI -19035 to -2492 pg/mL; P = .001) compared to the intervention start without between-intervention differences. Adiponectin (B) was reduced within eTRE only (-0.94 pg/mL; 95% CI -1.54 to -0.34 pg/mL, P = .003) and these changes differ from lTRE (1.28 pg/mL; 95% CI 0.20 to 2.36 pg/mL, P = .04 for lTRE vs. eTRE). Cytokines IL-6 (C), TNFα (D), MCP-1 (also known as CCL2) (E) were not affected by eTRE or lTRE intervention. Data are shown as means with 95% CI.
Article Snippet: Circulating levels of insulin (10-1113-01), C-peptide (10-1136-01) and glucagon (10-1271-01, all from Mercodia Inc., NC, USA), MCP-1 (DCP00, Quantikine®ELISA, R&D Systems Inc., MN, USA), IL-6 (HS600C) and TNF-α (HSTA00E, both Quantikine®ELISA HS, R&D Systems Inc., MN, USA), PYY (EZHPYYT66K, Merck Millipore, Germany), adiponectin (RD195023100, Biovendor, Germany), and leptin (DLP00, Quantikine®ELISA, R&D Systems Inc., MN, USA) were quantified using commercial ELISA kits using a DSX® 4-Plate ELISA Processing System (DYNEX Technologies GmbH, Denkendorf, Germany).
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